Mouse Anti-Human Perforin Monoclonal Antibody, Clone B-D48, Azide free

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Diaclone
Product Code: 854.950.000
Product Group: Primary Antibodies
Supplier: Diaclone
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854.950.000200ug/200ul£232.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-D48
Regulatory Status: RUO
Target Species: Human

Further Information

Antigen:
Perforin
Conjugate:
Azide free
Format:
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Natural human Perforin
Reactivity:
Human
Research Area:
Cytotoxic MoleculesInnate Immunity
Specificity:
Recognizes human Perforin a 70 kDa protein

References

  1. B?zie S. et al.Front Immunol. 2018 Jan 31;8:2014.. Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow/- Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice.. https://www.ncbi.nlm.nih.gov/pubmed/29445370
  2. de Rosa S.C. et al.J. Immunol. 2011; 187: 3391 - 3401. HIV-DNA Priming Alters T Cell Responses to HIV-Adenovirus Vaccine Even When Responses to DNA Are Undetectable. https://www.ncbi.nlm.nih.gov/pubmed/21844392
  3. Hersperger A. R. et al.PLoS Pathog.2010; 6(5): e1000917. Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control. https://www.ncbi.nlm.nih.gov/pubmed/20523897
  4. Hutnick N. A. et al et al.PLoS One2010; 5(12): e14385. Vaccination with Ad5 vectors expands Ad5-specific CD8 T cells without altering memory phenotype or functionality.. https://www.ncbi.nlm.nih.gov/pubmed/21203546
  5. Hutnick N. A. et al.Vaccine2010; 28(8): 1932-41. Adenovirus-specific human T cells are pervasive polyfunctional and cross-reactive.. https://www.ncbi.nlm.nih.gov/pubmed/20188249
  6. McElrath M. J. et al. Lancet2008; 372(9653): 1894-905.. HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. https://www.ncbi.nlm.nih.gov/pubmed/19012957
  7. Sanborn K. B. et al. J. Immunol.2009;182(11): 6969-6984.. Myosin IIA Associates with NK Cell Lytic Granules to Enable Their Interaction with F-Actin and Function at the Immunological Synapse. https://www.ncbi.nlm.nih.gov/pubmed/19454694