Mouse Anti-Human CD40 BioActive Antibody, Clone B-B20, Azide free

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Diaclone
Product Code: 854.280.000
Product Group: Primary Antibodies
Supplier: Diaclone
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854.280.000200ug/200ul£232.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-B20
Regulatory Status: RUO
Target Species: Human

Further Information

Activity:
Stimulates B-cell proliferation together with IL-4
Antigen:
CD40
Biological Acivity:
Stimulates B-cell proliferation together with IL-4
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Raji cell line
Reactivity:
Human
Research Area:
B Cell AntigensCD Markers
Specificity:
Recognises the Bp50 antigen a 48 kDa protein
Workshop:
VI

References

  1. Cagigi A. et al. PLoS One2009; 4(5): e5427.. CD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection. https://www.ncbi.nlm.nih.gov/pubmed/19412542
  2. De Goer de Herve M-G. et al. Blood 2005; 106(8) : 2806-14. Differential effect of agonistic anti-CD40 on human mature and immature dendritic cells. The Janus face of anti-CD40. https://www.ncbi.nlm.nih.gov/pubmed/15994291
  3. Durali D. et al. Blood 2003; 102(12) : 4084-4089. In human B cells IL-12 triggers a cascade of molecular events similar to Th1 commitment. https://www.ncbi.nlm.nih.gov/pubmed/12893768
  4. Jeannin P. et al. J Biol Chem1997; 272(25): 15613-9.. CD86 (B7-2) on human B cells. A functional role in proliferation and selective differentiation into IgE- and IgG4-producing cells. https://www.ncbi.nlm.nih.gov/pubmed/9188449
  5. Kap Y. S. et al. Journal of Histochemistry & Cytochemistry2009?; 57(12): 1159-1167.. A Monoclonal Antibody Selection for Immunohistochemical Examination of Lymphoid Tissues From Non-human Primates. https://www.ncbi.nlm.nih.gov/pubmed/19729671
  6. O'Neill A. M. et al.Cancer Biol Ther.2011; 11(7): 651-8. Resistance of canine lymphoma cells to adenoviral infection due to reduced cell surface RGD binding integrins.. https://www.ncbi.nlm.nih.gov/pubmed/21321486
  7. Puig-Kr?ger A. et al. Blood 2001; 98(7) : 2175 - 2182. Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. https://www.ncbi.nlm.nih.gov/pubmed/11568005
  8. Vermot-Desroches C. et al. Immunol Lett.1995; 48(1): 1-9.. Heterogeneity of antigen expression among human umbilical cord vascular endothelial cells: identification of cell subsets by co-expression of haemopoietic antigens. https://www.ncbi.nlm.nih.gov/pubmed/8847083
  9. Wassmer S. C. et al. Cell Microbiol.2011;13(2): 198-209. Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF.. https://www.ncbi.nlm.nih.gov/pubmed/21029292
  10. Wassmer S. C. et al. Infect Immun.2006; 74(1): 645-53.. Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum. https://www.ncbi.nlm.nih.gov/pubmed/16369021
  11. Wassmer S. C. et al. J Immunol.2006; 176(2): 1180-4.. TGF-beta1 released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: a new mechanism for microvascular lesion during cerebral malaria. https://www.ncbi.nlm.nih.gov/pubmed/16394007
  12. Wassmer S. C. et al.J Infect Dis.2004;189(2):180-9. Platelets reorient Plasmodium falciparum-infected erythrocyte cytoadhesion to activated endothelial cells. https://www.ncbi.nlm.nih.gov/pubmed/14722881