Mouse Anti-Human CD126 Monoclonal Antibody, Clone B-N12, Azide free
| Code | Size | Price |
|---|
| 852.050.005 | 500ug/500ul | £419.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-N12
Regulatory Status: RUO
Target Species: Human
Further Information
Antigen:
CD126 / IL-6R
Antigen Synonyms:
IL-6R / gp80
Conjugate:
Azide free
Format:
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
gp80 transfected CHO cell line
Reactivity:
Human
Research Area:
Cytokine / Chemokine ReceptorsCD Markers
Specificity:
Recognises the Interleukin-6 Ra subunit IL-6 Ra IL-6 R a 80 kDa protein
Workshop:
V - VI
References
- Blanchetot C. et al.J. Biol. Chem.2016?; 291(26): 13846-13854. Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies. https://www.ncbi.nlm.nih.gov/pubmed/27129274
- Fischer P. et al.Biochem J.2004;378(Pt 2): 449-60. The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.. https://www.ncbi.nlm.nih.gov/pubmed/14611646
- Kube D. et al. Blood 2001; 98(3) : 762 - 770. STAT3 is constitutively activated in Hodgkin cell lines. https://www.ncbi.nlm.nih.gov/pubmed/11468177
- Labbozzetta M. et al. Ann N Y Acad Sci.2006; 1089: 268-75.. Significance of autologous interleukin-6 production in the HA22T/VGH cell model of hepatocellular carcinoma. https://www.ncbi.nlm.nih.gov/pubmed/17261774
- Lebeau B. et al. FEBS Lett.1997; 407(2): 141-7.. Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties. https://www.ncbi.nlm.nih.gov/pubmed/9166888
- Mouthon M. A. et al. Blood1994; 84(4): 1085-97.. Growth and differentiation of the human megakaryoblastic cell line (ELF-153): a model for early stages of megakaryocytopoiesis. https://www.ncbi.nlm.nih.gov/pubmed/7519473
- Muller-Newen G. et al. Eur J Biochem.1996; 236(3): 837-42.. Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing. https://www.ncbi.nlm.nih.gov/pubmed/8665902
- Van Roy M. et al.Arthritis Res Ther.2015;17:135. The preclinical pharmacology of the high affinity anti-IL-6R Nanobody(R) ALX-0061 supports its clinical development in rheumatoid arthritis.. https://www.ncbi.nlm.nih.gov/pubmed/25994180