Mouse Anti-Human CD130 Monoclonal Antibody, Clone B-R3, Azide free

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Diaclone
Product Code: 852.060.005
Product Group: Primary Antibodies
Supplier: Diaclone
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852.060.005500ug/500ul£419.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: B-R3
Regulatory Status: RUO
Target Species: Human

Further Information

Activity:
Inhibits IL-6 IL-11 CNTF LIF and OSM activities
Antigen:
CD130 / gp130
Antigen Synonyms:
gp130
Biological Acivity:
Inhibits IL-6 IL-11 CNTF LIF and OSM activities
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Natural soluble gp130
Reactivity:
Human
Research Area:
Cytokine / Chemokine ReceptorsCD Markers
Specificity:
Recognises the Gp130 common subunit for IL-6 IL-11 OSM LIF CNTF CT-1 receptors a 130-140 kDa protein
Workshop:
VI

References

  1. Aoki Y. et al. Blood2001; 98(10): 3042-9.. Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus. https://www.ncbi.nlm.nih.gov/pubmed/11698289
  2. Auguste P. et al. J Biol Chem.1997; 272(25): 15760-4.. Signaling of type II oncostatin M receptor. https://www.ncbi.nlm.nih.gov/pubmed/9188471
  3. Blanchard F. et al. J. Biol. Chem. 1998; 273(33): 20886 -20893. The mannose 6-phosphate/insulin-like growth factor II receptor is a nanomolar affinity receptor for glycosylated human leukemia inhibitory factor. https://www.ncbi.nlm.nih.gov/pubmed/9694835
  4. Burger R. et al. The Haematology Journal 2001; 2(1): 42-53. Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma. https://www.ncbi.nlm.nih.gov/pubmed/11920233
  5. Burger R. et al.Haematologica 2017;102(2) :381-390. Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth. https://www.ncbi.nlm.nih.gov/pubmed/27658435
  6. Chautard E. et al.Neuro Oncology2010;12(5): 434-443. Akt signaling pathway: a target for radiosensitizing human malignant glioma. https://www.ncbi.nlm.nih.gov/pubmed/20406894
  7. Chevalier S. et al. J. Biol. Chem. 1996; 271(25): 14764-72. Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein. https://www.ncbi.nlm.nih.gov/pubmed/8662918
  8. Duplomb L. et al. Endocrinology 2003; 144(12) : 5381 - 5389. Soluble mannose 6-phosphate/insulin-like growth factor II (IGF-II) receptor inhibits interleukin-6-type cytokine-dependent proliferation by neutralization of IGF-II. https://www.ncbi.nlm.nih.gov/pubmed/12959977
  9. Gougelet A. et al.PLoS One2009; 4(11): e8026. Lymphoma and myeloma cell resistance to cytotoxic agents and ionizing radiations is not affected by exposure to anti-IL-6 antibody.. https://www.ncbi.nlm.nih.gov/pubmed/19956602
  10. Gu Z. J. et al. Blood1996; 88(10): 3972-86.. Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop. https://www.ncbi.nlm.nih.gov/pubmed/8916964
  11. Gu Z. J. et al. J Immunol Methods1996; 190(1): 21-7.. Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor interleukin-6 interleukin-11 leukemia inhibitory factor or oncostatin M. https://www.ncbi.nlm.nih.gov/pubmed/8601708
  12. Gu Z. J. et al. Leukemia2000; 14(1): 188-97.. Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors. https://www.ncbi.nlm.nih.gov/pubmed/10637495
  13. Jover R. et al. Faseb J.2002; 16(13): 1799-801.. Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved.. https://www.ncbi.nlm.nih.gov/pubmed/12354697
  14. Kube D. et al. Blood 2001; 98(3) : 762 - 770. STAT3 is constitutively activated in Hodgkin cell lines. https://www.ncbi.nlm.nih.gov/pubmed/11468177
  15. Lebeau B. et al. FEBS Lett.1997; 407(2): 141-7. Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties. https://www.ncbi.nlm.nih.gov/pubmed/9166888