Mouse Anti-Human CD130 Monoclonal Antibody, Clone B-P8, Azide free

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Diaclone
Product Code: 852.080.005
Product Group: Primary Antibodies
Supplier: Diaclone
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852.080.005500ug/500ul£419.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-P8
Regulatory Status: RUO
Target Species: Human

Further Information

Activity:
Inhibits CNTF activity and binding to gp130. Induces gp130 activation Jak 1 Jak 2 Stat 1 and Stat 3 phosphorylation
Antigen:
CD130 / gp130
Antigen Synonyms:
gp130
Biological Acivity:
Inhibits CNTF activity and binding to gp130. Induces gp130 activation Jak 1 Jak 2 Stat 1 and Stat 3 phosphorylation
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Natural soluble gp130
Reactivity:
Human
Research Area:
Cytokine / Chemokine ReceptorsCD Markers
Specificity:
Recognises the Gp130 common subunit for IL-6 IL-11 OSM LIF CNTF CT-1 receptors a 130-140 kDa protein
Workshop:
VI

References

  1. Aoki Y. et al. Blood2001; 98(10): 3042-9.. Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus. https://www.ncbi.nlm.nih.gov/pubmed/11698289
  2. Chevalier S. et al. J Biol Chem.1996; 271(25): 14764-72.. Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein. https://www.ncbi.nlm.nih.gov/pubmed/8662918
  3. Fischer P. et al.Biochem J.2004;378(Pt 2): 449-60. The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.. https://www.ncbi.nlm.nih.gov/pubmed/14611646
  4. Giese B. et al. J. Biol. Chem. 2003; 278(40) : 39205 - 39213. Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis. https://www.ncbi.nlm.nih.gov/pubmed/12878601
  5. Giese B. et al. J Cell Sci.2005; 118(Pt 21): 5129-40.. Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells. https://www.ncbi.nlm.nih.gov/pubmed/16254248
  6. Gu Z. J. et al. J Immunol Methods1996; 190(1): 21-7.. Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor interleukin-6 interleukin-11 leukemia inhibitory factor or oncostatin M. https://www.ncbi.nlm.nih.gov/pubmed/8601708
  7. Gu Z. J. et al. Leukemia2000; 14(1): 188-97.. Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors. https://www.ncbi.nlm.nih.gov/pubmed/10637495
  8. Haan C. et al. Biochem J.2000; 349(Pt 1): 261-6. A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1 and dominantly impairs signal transduction.. https://www.ncbi.nlm.nih.gov/pubmed/10861237
  9. Horsten U. et al. J Biol Chem;1997; 272(38): 23748-57.. Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex. https://www.ncbi.nlm.nih.gov/pubmed/9295319
  10. Kurth I. et al. J Immunol.2000; 164(1): 273-82.. Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130. https://www.ncbi.nlm.nih.gov/pubmed/10605021
  11. Lebeau B. et al. FEBS Lett.1997; 407(2): 141-7.. Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties. https://www.ncbi.nlm.nih.gov/pubmed/9166888
  12. M?ller-Newen G. et al. J. Biol. Chem. 2000; 275 (7) : 4578 - 4586. Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies. https://www.ncbi.nlm.nih.gov/pubmed/10671483
  13. Olivier C. et al. J Biol Chem.2000; 275(8): 5648-56.. Identification of a gp130 cytokine receptor critical site involved in oncostatin M response.. https://www.ncbi.nlm.nih.gov/pubmed/10681548
  14. Rebouissou C. et al. Blood 1998; 91(12) : 4727 - 4737. A gp130 interleukin-6 transducer-dependent SCID model of human multiple myeloma. https://www.ncbi.nlm.nih.gov/pubmed/9616171
  15. Simpson R. J. et al. Protein Sci.1997; 6(5): 929-55.. Interleukin-6: structure-function relationships. https://www.ncbi.nlm.nih.gov/pubmed/9144766