Mouse Anti-Human CD130 Monoclonal Antibody, Clone B-P4, Azide free

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Diaclone
Product Code: 852.090.005
Product Group: Primary Antibodies
Supplier: Diaclone
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852.090.005500ug/500ul£419.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-P4
Regulatory Status: RUO
Target Species: Human

Further Information

Activity:
Inhibits IL-11 activity and binding to gp130 but not CNTF LIF and OSM activities
Antigen:
CD130 / gp130
Antigen Synonyms:
gp130
Biological Acivity:
Inhibits IL-11 activity and binding to gp130 but not CNTF LIF and OSM activities
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Natural soluble gp130
Reactivity:
Human
Research Area:
Cytokine / Chemokine ReceptorsCD Markers
Specificity:
Recognises the Gp130 common subunit for IL-6 IL-11 OSM LIF CNTF CT-1 receptors a 130-140 kDa protein
Workshop:
VI

References

  1. Adam N. et al. J. Virol.2009; JVI.01601-08.. Unraveling Viral Interleukin 6 binding to gp130 and activation of STAT-Signaling Pathways independent of Interleukin 6-Receptor. https://www.ncbi.nlm.nih.gov/pubmed/19264784
  2. Anhuf D. et al. J Immunol.2000; 165(5): 2535-43.. Signal transduction of IL-6 leukemia-inhibitory factor and oncostatin M: structural receptor requirements for signal attenuation. https://www.ncbi.nlm.nih.gov/pubmed/10946280
  3. Aoki Y. et al. Blood2001; 98(10): 3042-9.. Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus. https://www.ncbi.nlm.nih.gov/pubmed/11698289
  4. Auguste P. et al. J Biol Chem.1997; 272(25): 15760-4.. Signaling of type II oncostatin M receptor.. https://www.ncbi.nlm.nih.gov/pubmed/9188471
  5. Buk D. M. et al. J. Cell Sci. 2004; 117(Pt 10): 2063 - 2075. Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells. https://www.ncbi.nlm.nih.gov/pubmed/15054106
  6. Campbell I. L. et al. J. Neurosci.2014 ; 34(7): 2503-2513. Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain. https://www.ncbi.nlm.nih.gov/pubmed/24523541
  7. Chevalier S. et al. J Biol Chem.1996; 271(25): 14764-72.. Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein. https://www.ncbi.nlm.nih.gov/pubmed/8662918
  8. Classen-Linke I. et al. Mol. Hum. Reprod. 2004; 10(7): 495 - 504. The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua. https://www.ncbi.nlm.nih.gov/pubmed/15133123
  9. Friederichs K. et al. Eur J Biochem2001; 268(24): 6401-7.. Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited.. https://www.ncbi.nlm.nih.gov/pubmed/11737194
  10. Gatsios P. et al. J Biol Chem.1998; 273(36): 22962-8.. Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock. https://www.ncbi.nlm.nih.gov/pubmed/9722518
  11. Giese B. et al. J. Biol. Chem. 2003; 278(40): 39205 - 39213. Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis. https://www.ncbi.nlm.nih.gov/pubmed/12878601
  12. Giese B. et al. J Cell Sci.2005; 118(Pt 21): 5129-40.. Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells. https://www.ncbi.nlm.nih.gov/pubmed/16254248
  13. Gu Z. J. et al. J Immunol Methods1996; 190(1): 21-7.. Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor interleukin-6 interleukin-11 leukemia inhibitory factor or oncostatin M. https://www.ncbi.nlm.nih.gov/pubmed/8601708
  14. Kurth I. et al. J. Immunol. 1999; 162(3) : 1480 -1487. Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes. https://www.ncbi.nlm.nih.gov/pubmed/9973404
  15. Kurth I. et al. J Immunol.2000; 164(1): 273-82.. Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130. https://www.ncbi.nlm.nih.gov/pubmed/10605021