Mouse Anti-Human CD18 Monoclonal Antibody, Clone MEM48, Azide free

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Diaclone
Product Code: 852.540.005
Product Group: Primary Antibodies
Supplier: Diaclone
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852.540.005500ug/500ul£583.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: MEM48
Regulatory Status: RUO
Target Species: Human

Further Information

Antigen:
CD18
Antigen Synonyms:
Integrin b 2
Biological Acivity:
Identification of CD18+ leukocytes. Blocks cell-cell interaction.
Conjugate:
Azide free
Format:
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Hybridoma:
Sp 2/0 - Ag 14 myeloma cell line
Immunisation:
Leucocytes from an LGL - type leukaemia
Reactivity:
Human
Research Area:
Cell AdhesionCD Markers
Specificity:
Recognizes the CD18 molecule a 95 kDa integrin molecule (β2 integrin) that forms the common beta chain of the CD11/CD18 heterodimer integrins.

References

  1. Kempers L. et al. Front Immunol. 2021; 12: 678030. . Defective Neutrophil Transendothelial Migration and Lateral Motility in ARPC1B Deficiency Under Flow Conditions. https://pubmed.ncbi.nlm.nih.gov/34135903/
  2. Martinez Sanz P. et al. J Immunother Cancer. 2021; 9(5): e002259. . G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment. https://pubmed.ncbi.nlm.nih.gov/34049929/
  3. Schim van der Loeff I. et al. J Allergy Clin Immunol. 2021 Jun; 147(6): 2381?2385.e2.. Defective neutrophil development and specific granule deficiency caused by a homozygous splice-site mutation in SMARCD2. https://pubmed.ncbi.nlm.nih.gov/33279574/
  4. Bazil V. et al. Fol. Biol. (Prague) 36 (1990). Monoclonal antibodies against human leucocyte antigens. IV. Antibodies against subunits of the LFA-1 (CD11a/CD18) leucocyte-adhesion glycoprotein.. https://www.ncbi.nlm.nih.gov/pubmed/1971601
  5. Larson R. S. & Springer T. A. Immunol Rev. 114 181-217 (1990). Structure and function of leukocyte integrins.. https://www.ncbi.nlm.nih.gov/pubmed/2196220
  6. Stefanova I & Horejsi V. J. Immunol 5 1587-1592 (1991). Association of the CD59 and CD55 cell surface glycoproteins with other membrane molecules.. https://www.ncbi.nlm.nih.gov/pubmed/1715364