Mouse Anti-Human IL-2 Monoclonal Antibody, Clone B-G5, Azide free

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Diaclone
Product Code: 855.020.005
Product Group: Primary Antibodies
Supplier: Diaclone
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855.020.005500ug/500ul£419.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-G5
Regulatory Status: RUO
Target Species: Human

Further Information

Activity:
Inhibits IL-2 induced proliferation on Kit 225 cell line
Antigen:
IL-2
Biological Acivity:
Inhibits IL-2 induced proliferation on Kit 225 cell line
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Natural human IL-2
Reactivity:
Human
Research Area:
Cytokines / Growth Factors
Specificity:
Recognises both natural and recombinant human IL-2

References

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  2. de Jong R. et al. J Immunol.1992;149(8): 2795-802.. Maturation- and differentiation-dependent responsiveness of human CD4+ T helper subsets. https://www.ncbi.nlm.nih.gov/pubmed/1328387
  3. Fisfalen M. E. et al. J Clin Endocrinol Metab.1997; 82(11): 3655-63.. Thyrotropin-receptor and thyroid peroxidase-specific T cell clones and their cytokine profile in autoimmune thyroid disease. https://www.ncbi.nlm.nih.gov/pubmed/9360522
  4. Fretier S. et al. J Leukoc Biol.2002; 71(2): 289-94.. Cyclosporin A inhibition of macrophage colony-stimulating factor (M-CSF) production by activated human T lymphocytes. https://www.ncbi.nlm.nih.gov/pubmed/11818450
  5. Groux H. et al. J Immunol.1998; 160(7): 3188-93.. Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells. https://www.ncbi.nlm.nih.gov/pubmed/9531274
  6. Heijink I. H. et al. Immunology2002; 107(3): 316-24. Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and -independent mechanisms in freshly isolated human T cells. https://www.ncbi.nlm.nih.gov/pubmed/12423307
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  8. Koopman G. et al. J. Gen. Virol. 2004; 85(Pt 10): 2915 - 2924. Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens. https://www.ncbi.nlm.nih.gov/pubmed/15448353
  9. Koopman G. et al. J. Gen. Virol.2008; 89(2): 540-5533.. Immune-response profiles induced by human immunodeficiency virus type 1 vaccine DNA protein or mixed-modality immunization: increased protection from pathogenic simian human immunodeficiency virus viraemia with protein/DNA combination. https://www.ncbi.nlm.nih.gov/pubmed/18198386
  10. Kuiper H. M. et al. Immunology1994; 83(1): 38-44.. Influence of CD28 co-stimulation on cytokine production is mainly regulated via interleukin-2. https://www.ncbi.nlm.nih.gov/pubmed/7821964
  11. Munoz N. M. et al. Am J Physiol Lung Cell Mol Physiol.2000; 278(6): L1172-9.. Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro.. https://www.ncbi.nlm.nih.gov/pubmed/10835322
  12. Oshima T. et al.Mol Cancer2013;12:60. Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers.. https://www.ncbi.nlm.nih.gov/pubmed/23758976
  13. Palmer E. M. and G. A. van Seventer J Immunol.1997; 158(6): 2654-62.. Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals. https://www.ncbi.nlm.nih.gov/pubmed/9058798
  14. Peng X. et al. J Immunol.1998; 160(3): 1166-72.. IL-12 up-regulates CD40 ligand (CD154) expression on human T cells. https://www.ncbi.nlm.nih.gov/pubmed/9570530
  15. Picker L. J. et al. Blood1995; 86(4): 1408-19.. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. https://www.ncbi.nlm.nih.gov/pubmed/7632949