Mouse Anti-Human IL-12 p35 Monoclonal Antibody, Clone B-T21, Azide free
| Code | Size | Price |
|---|
| 855.120.005 | 500ug/500ul | £419.00 |
Quantity:
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Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-T21
Regulatory Status: RUO
Target Species: Human
Further Information
Activity:
Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes
Antigen:
IL-12p35+p70
Antigen Synonyms:
IL-12p35/p70
Biological Acivity:
Inhibits IL-12 induced IFNg synthesis on PHA activated lymphocytes
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Recombinant human IL-12
Reactivity:
Human
Research Area:
Cytokines / Growth FactorsInnate Immunity
Specificity:
Recognises both natural and recombinant human IL-12 p35 + p70
References
- Kolanowski S. T. H. M. et al. Innate Immunity2013: 1753425913498626.. TLR4-mediated pro-inflammatory dendritic cell differentiation in humans requires the combined action of MyD88 and TRIF.. https://www.ncbi.nlm.nih.gov/pubmed/23941760
- Nagai T. et al. J Immunol.2003; 171(10): 5233-43.. Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation. https://www.ncbi.nlm.nih.gov/pubmed/14607924
- Oppmann B. et al. Immunity2000; 13(5): 715-25.. Novel p19 protein engages IL-12p40 to form a cytokine IL-23 with biological activities similar as well as distinct from IL-12.. https://www.ncbi.nlm.nih.gov/pubmed/11114383