Mouse Anti-Human TNF-a Monoclonal Antibody, Clone B-C7, Azide free

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Diaclone
Product Code: 855.150.005
Product Group: Primary Antibodies
Supplier: Diaclone
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855.150.005500ug/500ul£419.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-C7
Regulatory Status: RUO
Target Species: Human

Further Information

Activity:
Inhibits TNF? induced cytotoxicity on U937 cells
Antigen:
TNF alpha
Antigen Synonyms:
TNFa
Biological Acivity:
Inhibits TNFα induced cytotoxicity on U937 cells
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Recombinant human TNF-a
Reactivity:
Human
Research Area:
Cytokines / Growth FactorsInnate Immunity
Specificity:
Recognises both natural and recombinant human TNF-a

References

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  2. Boillot A. et al. Clin Intensive Care1995; 6(2): 52-6.. Pilot clinical trial of an anti-TNF alpha monoclonal antibody for the treatment of septic shock. https://www.ncbi.nlm.nih.gov/pubmed/10150799
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  4. Hamacher J. et al. Am J Respir Crit Care Med.2002; 166(5): 651-6.. Tumor necrosis factor-alpha and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome.. https://www.ncbi.nlm.nih.gov/pubmed/12204860
  5. Herve P. et al. Blood1992; 79(12): 3362-8.. Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease. https://www.ncbi.nlm.nih.gov/pubmed/1596576
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  10. Mey A. et al. J Leukoc Biol.1997; 61(1): 17-23.. Alteration of dealcylated lipopolysaccharide antagonistic properties by interaction with plasma factors. https://www.ncbi.nlm.nih.gov/pubmed/9000532
  11. Musey L. et al. J Virol.2003; 77(1): 291-300.. Ontogeny and specificities of mucosal and blood human immunodeficiency virus type 1-specific CD8(+) cytotoxic T lymphocytes. https://www.ncbi.nlm.nih.gov/pubmed/12477834
  12. Racadot E. et al. Bone Marrow Transplant1995; 15(5): 669-77.. Sequential use of three monoclonal antibodies in corticosteroid-resistant acute GVHD: a multicentric pilot study including 15 patients. https://www.ncbi.nlm.nih.gov/pubmed/7670394
  13. Sabour Alaoui S. et al.PLoS One2012;7(3): e33609. TWEAK affects keratinocyte G2/M growth arrest and induces apoptosis through the translocation of the AIF protein to the nucleus.. https://www.ncbi.nlm.nih.gov/pubmed/22438963
  14. van Hensbroek M. B. et al. J Infect Dis.1996; 174(5): 1091-7.. The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria.. https://www.ncbi.nlm.nih.gov/pubmed/8896514
  15. Venet F. et al. J Immunol.2006; 177(9): 6540-7.. Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism. https://www.ncbi.nlm.nih.gov/pubmed/17056586