Mouse Anti-Human IL-15 Monoclonal Antibody, Clone B-E29, Azide free

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Diaclone
Product Code: 855.220.005
Product Group: Primary Antibodies
Supplier: Diaclone
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855.220.005500ug/500ul£419.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-E29
Regulatory Status: RUO
Target Species: Human

Further Information

Activity:
Inhibits IL-15 induced proliferation on Kit 225 cell line
Antigen:
IL-15
Biological Acivity:
Inhibits IL-15 induced proliferation on Kit 225 cell line
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Recombinant human IL-15
Reactivity:
Human
Research Area:
Cytokines / Growth Factors
Specificity:
Recognises both natural and recombinant human IL-15

References

  1. Bernard J. et al. J. Biol. Chem. 2004; 279(23): 24313 - 24322. Identification of an Interleukin-15a Receptor-binding Site on Human Interleukin-15. https://www.ncbi.nlm.nih.gov/pubmed/15039446
  2. Bouchaud G. et al.J. Exp. Med.2013 ; 210(10): 2105-2117.. Epidermal IL-15R{alpha} acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.. https://www.ncbi.nlm.nih.gov/pubmed/24019554
  3. Debili N.et al. Blood2001; 97(7): 2023-2030.. Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates.. https://www.ncbi.nlm.nih.gov/pubmed/11264167
  4. Ernestam S. et al. Arthritis Res Ther.2006; 8(1): R18. Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor. https://www.ncbi.nlm.nih.gov/pubmed/16507118
  5. Finch D. K. et al.Br J Pharmacol.2011;162(2): 480-90. Identification of a potent anti-IL-15 antibody with opposing mechanisms of action in vitro and in vivo.. https://www.ncbi.nlm.nih.gov/pubmed/20942844
  6. Lebre M. C. et al.Am. J. Pathol.2008; 172(4): 940-950.. Rheumatoid Arthritis Synovium Contains Two Subsets of CD83-DC-LAMP- Dendritic Cells with Distinct Cytokine Profiles.. https://www.ncbi.nlm.nih.gov/pubmed/18292234
  7. Suzuki K. et al. Blood2000; 96(6): 2172-2180.. Role of common cytokine receptor gamma chain (gamma c)- and Jak3-dependent signaling in the proliferation and survival of murine mast cells. https://www.ncbi.nlm.nih.gov/pubmed/10979963
  8. Tamzalit F. et al.PNAS2014: 1405514111. IL-15.IL-15R{alpha} complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells. https://www.ncbi.nlm.nih.gov/pubmed/24912180
  9. van der Meer J. J. et al.Int J Clin Exp Pathol.2011; 4(3): 287-94. Smooth muscle homeostasis in human atherosclerotic plaques through interleukin 15 signalling.. https://www.ncbi.nlm.nih.gov/pubmed/21487524