Deltamethrin
| Code | Size | Price |
|---|
| CDX-D0619-M250 | 250 mg | £86.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
Short term: +20°C, Long term: +20°C
Documents
Further Information
Appearance:
White to light yellow powder.
CAS:
52918-63-5
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS06, GHS09
Handling Advice:
Protect from light and moisture.
Hazards:
H301 + H331 - H410
InChi:
InChI=1S/C22H19Br2NO3/c1-22(2)17(12-19(23)24)20(22)21(26)28-18(13-25)14-7-6-10-16(11-14)27-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3/t17-,18,20-/m0/s1
InChiKey:
OWZREIFADZCYQD-DXCJPMOASA-N
Long Description:
Chemical. CAS: 52918-63-5. Formula: C22H19Br2NO3. MW: BD9837. Deltamethrin belongs to the class of synthetic pyrethroids, which are being widely used as insecticides. Deltamethrin acts on voltage-gated sodium channels (VGSCs) and voltage-gated calcium channels (VGCCs) that are the primary targets of these chemicals for toxicity to insects. Deltamethrin can increase neurotransmitter release which is associated with elevated levels of intrasynaptosomal free Ca2+ and protein phosphorylation activities. It acts as a potent inhibitor of calcineurin (protein phosphatase 2B), which results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca2+ to enter the cell. It also modulates sodium channels in the nerve cell membrane. It keeps the Na+ channels in an open state for a long time resulting to hyperactivity of the nervous system in mammals and insects. This compound can be used as a reference compound for analytical studies.
MDL:
MFCD00870122
Molecular Formula:
C22H19Br2NO3
Molecular Weight:
505.2
Package Type:
Vial
PG:
III
Precautions:
P261 - P264 - P270 - P273 - P301 + P310 - P304 + P340 + P311
Product Description:
Deltamethrin belongs to the class of synthetic pyrethroids, which are being widely used as insecticides. Deltamethrin acts on voltage-gated sodium channels (VGSCs) and voltage-gated calcium channels (VGCCs) that are the primary targets of these chemicals for toxicity to insects. Deltamethrin can increase neurotransmitter release which is associated with elevated levels of intrasynaptosomal free Ca2+ and protein phosphorylation activities. It acts as a potent inhibitor of calcineurin (protein phosphatase 2B), which results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca2+ to enter the cell. It also modulates sodium channels in the nerve cell membrane. It keeps the Na+ channels in an open state for a long time resulting to hyperactivity of the nervous system in mammals and insects. This compound can be used as a reference compound for analytical studies.
Purity:
>97% (HPLC)
Signal Word:
Danger
SMILES:
O=C(O[C@H](C#N)C1=CC=CC(OC2=CC=CC=C2)=C1)[C@H]3C(C)(C)[C@H]3/C=C(Br)/Br
Solubility Chemicals:
Soluble in DMSO (15 mg/ml) or ethanol (1 mg/ml). Insoluble in water.
Source / Host:
Synthetic.
Transportation:
Excepted Quantity
UN Nummer:
UN2811
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) K. Chinn & T. Narahashi; J. Physiol. 380, 191 (1986) | (2) E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) | (3) T. Narahashi; Trends Pharmacol. Sci. 13, 236 (1992) | (4) E. Enan & F. Matsumura; Biochem. Pharmacol. 45, 703 (1993) | (5) S.B. Symington & J.M. Clark; Pest. Biochem. Physiol. 82, 1 (2005) | (6) J.M. Clark & S.B. Symington; Invert. Neurosci. 7, 3 (2007) | (7) R. Zeng, et al.; Pestic. Biochem. Physiol. 138, 84 (2017) | (8) S.N. Bothe & A. Lampert; Toxicol. Appl. Pharmacol. 428, 115676 (2021)