N-Nitrosopyrrolidine (NPYR)
| Code | Size | Price |
|---|
| CDX-N0378-G001 | 1 g | £92.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
Short term: +4°C, Long term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
NPYR; NSC 18797; BRN 0107615
Appearance:
Pale yellow to yellow brown liquid.
CAS:
930-55-2
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07, GHS08
Handling Advice:
Protect from light and moisture.
Hazards:
H302+H351
InChi:
InChI=1S/C4H8N2O/c7-5-6-3-1-2-4-6/h1-4H2
InChiKey:
WNYADZVDBIBLJJ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 930-55-2. Formula: C4H8N2O. MW: 100.12. N-Nitrosopyrrolidine (NPYR) is a nitrosamine and is known to be a potent carcinogen associated with cancer development in animals and humans. NPYR can damage DNA and cause mutations in genes that control cell growth and division. It reacts with DNA in vitro to form genotoxic activity, which may lead to cell death or mutagenesis. NPYR is formed in various industrial processes, including the synthesis of certain chemicals where it is used as an organic solvent, pharmaceutical intermediate, and plasticizer. Functions as an analytical reagent for environmental monitoring. This compound can be used as analytical reference material. NPYR could be used as a tumor initiator, as a reagent for preparing carcinogenic animal diseases model. NPYR has also neurological effects, inhibiting NMDA receptors.
MDL:
MFCD00003166
Molecular Formula:
C4H8N2O
Molecular Weight:
100.12
Package Type:
Vial
Precautions:
P201, P270, P281, P301+P312, P308+P313, P330, P501
Product Description:
N-Nitrosopyrrolidine (NPYR) is a nitrosamine and is known to be a potent carcinogen associated with cancer development in animals and humans. NPYR can damage DNA and cause mutations in genes that control cell growth and division. It reacts with DNA in vitro to form genotoxic activity, which may lead to cell death or mutagenesis. NPYR is formed in various industrial processes, including the synthesis of certain chemicals where it is used as an organic solvent, pharmaceutical intermediate, and plasticizer. Functions as an analytical reagent for environmental monitoring. This compound can be used as analytical reference material. NPYR could be used as a tumor initiator, as a reagent for preparing carcinogenic animal diseases model. NPYR has also neurological effects, inhibiting NMDA receptors.
Purity:
>95% (NMR)
Signal Word:
Warning
SMILES:
C1CCN(C1)N=O
Solubility Chemicals:
Soluble in chloroform.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) W. Lijinsky & H.W. Taylor; Cancer Res. 36, 1988 (1976) | (2) Y.Y. Fong & W.C. Chan; Food Cosmet. Toxicol. 15, 143 (1977) | (3) S.S. Hecht, et al.; Cancer Res. 38, 215 (1978) | (4) J.I. Gray & M.E. Collins; J. Food Prot. 41, 36 (1978) | (5) M. Habs, et al.; Int. J. Cancer 26, 47 (1980) | (6) E.J. Hunt & R.C. Shank; BBRC 104, 1343 (1982) | (7) O. Manzoni, et al.; Neuron 8, 653 (1992) | (8) S. Krishnan, et al.; Chem. Commun. 17, 1713 (2007) | (9) Y. Li & S.S. Hecht; Int. J. Mol. Sci. 23, 4559 (2022) | (10) M. Bignami, et al.; Efsa J. 21, e07884 (2023)