Phloretin
| Code | Size | Price |
|---|
| CDX-P0487-M100 | 100 mg | £57.00 |
Quantity:
| CDX-P0487-M250 | 250 mg | £103.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
Ambient
Storage:
Short term: +20°C, Long term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
Appearance:
White to off-white powder.
CAS:
60-82-2
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315 - H319 - H335
InChi:
InChi=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
InChiKey:
VGEREEWJJVICBM-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 60-82-2. Formula: C15H14O5. MW: 274.27. Phloretin is a natural dihydrochalcone, originally identified from the apple tree, and is a metabolite of phlorizin. It has numerous pharmacological effects, including anti-inflammatory, antidiabetic, anticancer, antimicrobial, hepatoprotective, neuroprotective and cytoprotective properties. Phloretin is a potent antioxidant, scavenging peroxynitrite (ONOO-) and/or suppressing lipid peroxidation, which contributes to the many biological properties. Phloretin has anti-aging and depigmenting effects, making it also attractive for dermatological research and application. Phloretin attacks a number of molecular targets, modulating different intracellular signaling pathways, including NF-kappaB, MAPK, Nrf2, and AMPK. It can modulate Ca2+ channels, PKC, GLUTs, SGLTs and other targets. The anticancer potential is based on antiproliferative, proapoptotic, antimetastatic, and antiangiogenic activities.
MDL:
MFCD00002288
Molecular Formula:
C15H14O5
Molecular Weight:
274.27
Package Type:
Vial
Precautions:
P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
Product Description:
Phloretin is a natural dihydrochalcone, originally identified from the apple tree, and is a metabolite of phlorizin. It has numerous pharmacological effects, including anti-inflammatory, antidiabetic, anticancer, antimicrobial, hepatoprotective, neuroprotective and cytoprotective properties. Phloretin is a potent antioxidant, scavenging peroxynitrite (ONOO-) and/or suppressing lipid peroxidation, which contributes to the many biological properties. Phloretin has anti-aging and depigmenting effects, making it also attractive for dermatological research and application. Phloretin attacks a number of molecular targets, modulating different intracellular signaling pathways, including NF-kappaB, MAPK, Nrf2, and AMPK. It can modulate Ca2+ channels, PKC, GLUTs, SGLTs and other targets. The anticancer potential is based on antiproliferative, proapoptotic, antimetastatic, and antiangiogenic activities.
Purity:
>98% (HPLC)
Signal Word:
Warning
SMILES:
Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
Solubility Chemicals:
Soluble in DMSO, ethanol or methanol. Insoluble in water.
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) M.R. de Oliveira; Biofactors 42, 13 (2016) (Review) | (2) B.Y. Choi; Molecules 24, 278 (2019) (Review) | (3) T.P.A. Casarini, et al.; Eur. J. Pharmacol. 889, 173593 (2020) (Review) | (4) K.T. Nakhate, et al.; Nutrients 14, 3638 (2022) (Review) | (5) H.S. Tuli, et al.; Molecules 27, 8819 (2022) (Review) | (6) S. Habtemariam;, Biomedicines 11, 143 (2023) (Review)