Pravastatin sodium salt hydrate
| Code | Size | Price |
|---|
| CDX-P0933-M050 | 50 mg | £80.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
Short term: +20°C, Long term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
Eptastatin sodium salt; 3beta-Hydroxycompactin; Mevalothin
Appearance:
White crystalline solid.
CAS:
81131-70-6 (sodium salt) | 81093-37-0 (free acid)
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18-,19-,20-,22-;/m0./s1
InChiKey:
VWBQYTRBTXKKOG-BAWPFLGFSA-M
Long Description:
Chemical. CAS: 81131-70-6 (sodium salt) | 81093-37-0 (free acid). Formula: C23H35O7Na. MW: BD9837. Pravastatin is a water-soluble, orally effective, competitive inhibitor of Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (Ki = 2.3nM), the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the statin class of cholesterol-lowering/regulating compounds. Pravastatin potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties. Pravastatin reduces LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. Pravastatin also acts as an immunomodulator and as an inhibitor of p21ras isoprenylation.
MDL:
MFCD18253021
Molecular Formula:
C23H35O7Na
Molecular Weight:
446.51
Package Type:
Vial
Product Description:
Pravastatin is a water-soluble, orally effective, competitive inhibitor of Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (Ki = 2.3nM), the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the statin class of cholesterol-lowering/regulating compounds. Pravastatin potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties. Pravastatin reduces LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. Pravastatin also acts as an immunomodulator and as an inhibitor of p21ras isoprenylation.
Purity:
> 98% (HPLC)
SMILES:
O[C@H]1C[C@H](OC([C@@H](C)CC)=O)[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@](O)([H])C[C@H](O)CC(O[Na])=O)=C1
Solubility Chemicals:
Soluble in water (30mg/ml) or DMSO (30mg/ml).
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) T. Koga, et al.; Biochim. Biophys. Acta 1045, 115 (1990) | (2) S.M. Singhvi, et al.; Br. J. Clin. Pharmacol. 29, 239 (1990) | (3) A. Corsini, et al.; Pharmacol. Res. 31, 9 (1995) | (4) B.A. Hamelin & J. Turgeon; Trends Pharmacol. Sci. 19, 26 (1998) | (5) M. Tatsuta, et al.; Br. J. Cancer 77, 581 (1998) | (6) W.H. Kaesemeyer, et al.; J. Am. Coll. Cardiol. 33, 234 (1999) | (7) B. Kwak, et al.; Nat Med. 6, 1399 (2000) | (8) J.A. Tobert; Nat. Rev. Drug Discov. 2, 517 (2003) | (9) A.A. Al-Badr, et al.; Prof. Drug Subst. Excip. Rel. Methodol. 39, 433 (2014)