Recombinant Human IL-23R (C-6His)

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ELK Biotechnology
Product Code: ELK-EPT034
Product Group: Recombinant Proteins
CodeSizePrice
ELK-EPT034-10ug10ug£227.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Human
Regulatory Status: RUO
Shipping:
The product is shipped at ambient temperature.
Storage:
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Further Information

Accession:
AAM44229.1
Alternative Names:
Interleukin-23 receptor; IL23R; IL-23 receptor; IL-23R
Apparent Molecular Weight:
60-90 KDa, reducing conditions
Background:
Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
Biological Activity:
Immobilized Human IL-23R-His(Cat#CP20) at 5ug/ml (100 ul/well)can bind Human IL-23-Fc (Cat#CW93).The ED50 of Human IL-23-Fc (Cat#CW93) is 0.187 ug/ml.
Endotoxin:
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Molecular Weight:
38.7 KDa
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Redissolve:
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100ug/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.?