Recombinant Human ACE-2 (C-6His)
| Code | Size | Price |
|---|
| ELK-EPT135-50ug | 50ug | £758.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
The product is shipped on dry ice/polar packs.
Storage:
Store at -70°C, stable for 6 months after receipt. Store at -70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Further Information
Accession:
Q9BYF1
Alternative Names:
Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
Apparent Molecular Weight:
103 KDa, reducing conditions
Background:
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don?t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Biological Activity:
Immobilized Human ACE-2-His(Cat#C419) at 2ug/ml (100 ul/well)can bind 2019-nCoV S Protein RBD-Fc(Cat#DRA121). The ED50 of 2019-nCoV S Protein RBD (N501Y, C-Fc)(Cat#DRA121) is 3.57 ng/ml.
Endotoxin:
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Molecular Weight:
84.63 KDa
Purity:
Greater than 95% as determined by reducing SDS-PAGE.