Biotinylated Human TGF-beta 1 (N-Avi)
| Code | Size | Price |
|---|
| ELK-EPT203-20ug | 20ug | £1,159.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
The product is shipped at ambient temperature.
Storage:
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Further Information
Accession:
P01137
Alternative Names:
Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB
Apparent Molecular Weight:
12-18 KDa, reducing conditions
Background:
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Biological Activity:
Measured by its ability to inhibit TGF-beta 1 activity on TF-1 human erythroleukemic cells.The ED50?for this effect is 137.37pg/ml.
Endotoxin:
Less than 0.001ng/ug (0.01EU/ug) as determined by LAL test.
Molecular Weight:
14.6 KDa
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Redissolve:
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100ug/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.?