CYP2E1 Antibody / Cytochrome P450 2E1 [Clone 2C7G1] (Antigen affinity purified)

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NSJ Bioreagents
Product Code: NSJ-RQ6970
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-RQ6970-100ug100 ug£535.00
Quantity:
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Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: 2C7G1
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
After reconstitution, the Cytochrome P450 2E1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Images

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Western blot testing of 1) human HCCP, 2) rat liver and 3) mouse liver lysate with Cytochrome P450 2E1 antibody. Predicted molecular weight ~57 kDa.
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Western blot testing of 1) human HCCP, 2) rat liver and 3) mouse liver lysate with Cytochrome P450 2E1 antibody. Predicted molecular weight ~57 kDa.

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Further Information

Application Details:
Western blot: 0.5-1 ug/ml
Application Note:
Optimal dilution of the Cytochrome P450 2E1 antibody should be determined by the researcher.
Buffer:
Lyophilized from 1X PBS with 2% Trehalose
Description:
Cytochrome P450 2E1 (abbreviated CYP2E1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. In humans, the CYP2E1 enzyme is encoded by the CYP2E1 gene. It is mapped to 10q26.3. While it is involved in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1. Most drugs undergo deactivation by CYP2E1, either directly or by facilitated excretion from the body. Also, many substances are bioactivated by CYP2E1 to form their active compounds. In addition, CYP2E1 is an important enzyme for the conversion of ethanol to acetaldehyde and to acetate in humans. In the conversion sequence of acetyl-CoA to glucose, CYP2E1 transforms acetone via acetol into propylene glycol and methylglyoxal, the precursors of pyruvate, acetate and lactate.
Format:
Antigen affinity purified
Formulation:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
Recombinant human Cytochrome P450 2E1/CYP2E1 protein (amino acids H355-S493) was used as the immunogen for the Cytochrome P450 2E1 antibody.
Limitation:
This Cytochrome P450 2E1 antibody is available for research use only.
Purity:
Antigen affinity purified
Uniprot #:
P05181