Nectin-4 Antibody / PVRL4 [Clone NECT4/7271] (Purified)

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NSJ Bioreagents
Product Code: NSJ-V4056
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-V4056-20UG20 ug£264.00
Quantity:
NSJ-V4056-100UG100 ug£534.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG2a, kappa
Antibody Clonality: Monoclonal
Antibody Clone: NECT4/7271
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
Aliquot the PVRL4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Images

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IHC staining of FFPE human placental tissue with PVRL4 antibody (clone NECT4/7271). Negative control inset: PBS used instead of primary antibody to control for secondary Ab binding.
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IHC staining of FFPE human placental tissue with PVRL4 antibody (clone NECT4/7271). Negative control inset: PBS used instead of primary antibody to control for secondary Ab binding.

Documents

Further Information

Application Details:
Immunohistochemistry (FFPE): 1-2ug/ml
Application Note:
Optimal dilution of the PVRL4 antibody should be determined by the researcher.
Description:
Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4). The ectodomain of nectin family members comprises three Ig-like domains (V, C, C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the actin cytoskeleton through its interaction with the actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta.
Format:
Purified
Formulation:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
A portion of amino acids 1-200 from the human protein was used as the immunogen for the PVRL4 antibody.
Limitation:
This PVRL4 antibody is available for research use only.
Localization:
Cell surface, secreted
Purity:
Protein A/G affinity
Uniprot #:
Q96NY8