POGZ Antibody / Pogo transposable element with ZNF domain

Flow cytometry: 1-2ug/million cells

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Recombinant full-length human Pogo transposable element with ZNF domain protein was used as the immunogen for the POGZ antibody.

This POGZ antibody is available for research use only.

Nucleus

Protein A/G affinity

Q7Z3K3