KChIP2 Antibody / KCNIP2
| Code | Size | Price |
|---|
| NSJ-V4120-20UG | 20 ug | £264.00 |
Quantity:
| NSJ-V4120-100UG | 100 ug | £534.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: KCNIP2/7588
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
Aliquot the KCNIP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details:
Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
Description:
In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents control the excitability of neurons and cardiac myocytes. KChIPs are Kv channel-interacting proteins that bind to the cytoplasmic amino termini of Kv4Alpha-subunits and are integral components of native Kv4 channel complexes. KChIP family members include KChIP1 expressed in brain, KChIP2 (KCNIP2) expressed in heart, brain, and lung, and KChIP3 (previously identified as calsenilin) expressed in brain and testis. In rat brain, KChIP1 colocalizes with Kv4.3 in granule cells and KChIP2 colocalizes with Kv4.2 in both neocoritcal and subcortical structures. The KChIPs are members of the recoverin/neuronal calcium sensor-1 subfamily of calcium-binding proteins and show 99% nucleotide homology to DREAM, suggesting that KChIPs may have activity beyond modulation of Kv4 channels.
Format:
Purified
Formulation:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
A recombinant partial protein (within amino acids 1-270) from the human protein was used as the immunogen for the KCNIP2 antibody.
Limitation:
This KCNIP2 antibody is available for research use only.
Localization:
Cell membrane
Purity:
Protein A/G affinity
Uniprot #:
Q9NS61