GPRC5A Antibody / Retinoic acid-induced protein 3 / PEIG-1
| Code | Size | Price |
|---|
| NSJ-V4236-20UG | 20 ug | £264.00 |
Quantity:
| NSJ-V4236-100UG | 100 ug | £534.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: GPRC5A/7893
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
Aliquot the PEIG-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details:
Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
Description:
Retinoic acid-induced protein 3 (RAI3), also called Phorbol ester induced gene 1 (PEIG-1) and GPRC5A, is an transmembrane G protein-coupled receptor that affects many essential biological processes including embryogenesis, cell growth, differentiation, and apoptosis. PEIG-1 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate PEIG-1 during its transcription in embryonal carcinoma differentiation. PEIG-1 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of PEIG-1 and represses its expression at the beginning of apoptosis. PEIG-1 is a potential molecular target for diagnosing breast cancer, and selective suppression of signals from PEIG-1 may have a place in breast cancer treatments.
Format:
Purified
Formulation:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
A recombinant partial protein sequence (within amino acids 200-357) from the human protein was used as the immunogen for the PEIG-1 antibody.
Limitation:
This PEIG-1 antibody is available for research use only.
Localization:
Cell membrane, Cytoplasmic
Purity:
Protein A/G affinity
Uniprot #:
Q8NFJ5