IRF3 Antibody

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NSJ Bioreagents
Product Code: NSJ-V4643
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-V4643-20UG20 ug£264.00
Quantity:
NSJ-V4643-100UG100 ug£534.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG1
Antibody Clonality: Monoclonal
Antibody Clone: PCRP-IRF3-4D7
Regulatory Status: RUO
Target Species: Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
Aliquot the Interferon regulatory factor 3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Images

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Flow cytometry testing of PFA-fixed human HeLa cells with Interferon regulatory factor 3 antibody (clone PCRP-IRF3-4D7) followed by goat anti-mouse IgG-CF488 (blue); Red = unstained cells.~
2 / 2
IHC staining of FFPE human tumor of unknown origi
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Flow cytometry testing of PFA-fixed human HeLa cells with Interferon regulatory factor 3 antibody (clone PCRP-IRF3-4D7) followed by goat anti-mouse IgG-CF488 (blue); Red = unstained cells.~
IHC staining of FFPE human tumor of unknown origi

Documents

Further Information

Application Details:
Flow cytometry: 1-2ug/million cells,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Description:
Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-Alpha and beta) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-Alpha and interferon-beta genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3gammap48 and IFN consensus sequence-binding protein (ICSBP).
Format:
Purified
Formulation:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
Recombinant full-length human IRF3 protein was used as the immunogen for the Interferon regulatory factor 3 antibody.
Limitation:
This Interferon regulatory factor 3 antibody is available for research use only.
Localization:
Cytoplasm, Nucleus
Purity:
Protein A/G affinity
Uniprot #:
Q14653