Beta-Parvin Antibody
| Code | Size | Price |
|---|
| NSJ-V4865SAF-100UG | 100 ug | £534.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG, kappa
Antibody Clonality: Monoclonal
Antibody Clone: PARVB/8214R
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
Aliquot the Beta-Parvin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details:
Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Description:
Beta-parvin, also known as affixin, is a focal adhesion protein belonging to a family of ILKbinding proteins that contain tandem calponin homolog domains. Along with Alpha-parvin, Beta-parvin is one of the most widely researched and characterized members of this family. These two proteins interact with the ILK kinase domain in a way that is mutually exclusive and regulates both the activity of the kinase and actin cytoskeleton adhesion. Studies have shown Beta-parvin to be downregulated within human breast cancer cells, and that its expression may influence the progression of breast cancer (Johnstone, 2008). Additional research indicates a critical role for Beta-parvin in the regulation of cardiac contractility when it is in complex with ILK (Hannigan, 2007).
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
The N-terminal region (residues 1-91) of the human protein was used as the immunogen for the Beta-Parvin antibody.
Limitation:
This Beta-Parvin antibody is available for research use only.
Localization:
Cell Surface, Cytoplasm
Purity:
Protein A/G affinity
Uniprot #:
Q9HBI1