HGAL Antibody / GCSAM / GCET2

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NSJ Bioreagents
Product Code: NSJ-V4982
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-V4982-20UG20 ug£264.00
Quantity:
NSJ-V4982-100UG100 ug£534.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: HGAL/2834
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
Aliquot the GCSAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Images

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Analysis of a HuProt(TM) microarray containing more than 19,000 full-length human proteins using GCSAM antibody (clone HGAL/2834). These results demonstrate the foremost specificity of the HGAL/2834 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a f
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Analysis of a HuProt(TM) microarray containing more than 19,000 full-length human proteins using GCSAM antibody (clone HGAL/2834). These results demonstrate the foremost specificity of the HGAL/2834 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a f

Documents

Further Information

Application Details:
Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Description:
Recognizes a protein identified as HGAL, also called GCSAM (Germinal center-associated signaling and motility protein). It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL).
Format:
Purified
Formulation:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the GCSAM antibody.
Limitation:
This GCSAM antibody is available for research use only.
Localization:
Cytoplasm, Cell membrane
Purity:
Protein A/G affinity
Uniprot #:
Q8N6F7