Glutathione Peroxidase 4 Antibody / GPX4

Western blot: 0.5-1ug/ml

Optimal dilution of the Glutathione Peroxidase 4 antibody should be determined by the researcher.

Lyophilized from 1X PBS with 2% Trehalose

Glutathione peroxidase 4, also known as GPX4, is an enzyme that in humans is encoded by the GPX4 gene. This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Recombinant human protein (amino acids A30-F197) was used as the immunogen for the Glutathione Peroxidase 4 antibody.

This Glutathione Peroxidase 4 antibody is available for research use only.

Antigen affinity purified

P36969