EAG1 Antibody / KCNH1

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NSJ Bioreagents
Product Code: NSJ-RQ7297
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-RQ7297-100UG100 ug£535.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Rat
Application: Western Blot (WB)
Storage:
After reconstitution, the EAG1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Images

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Western blot testing of 1) human U-87 MG, 2) human SH-SY5Y, 3) human HeLa, 4) human MCF7, 5) rat brain and 6) rat C6 cell lysate with EAG1 antibody. Predicted molecular weight ~111 kDa (may be observed larger than predicted due to glycosylation).
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Western blot testing of 1) human U-87 MG, 2) human SH-SY5Y, 3) human HeLa, 4) human MCF7, 5) rat brain and 6) rat C6 cell lysate with EAG1 antibody. Predicted molecular weight ~111 kDa (may be observed larger than predicted due to glycosylation).

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Further Information

Application Details:
Western blot: 0.5-1ug/ml
Application Note:
Optimal dilution of the EAG1 antibody should be determined by the researcher.
Buffer:
Lyophilized from 1X PBS with 2% Trehalose
Description:
Potassium voltage-gated channel subfamily H member 1, also called Ether-a-go-go potassium channel 1 (h-eag, EAG1) is a protein that in humans is encoded by the KCNH1 gene. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
Format:
Antigen affinity purified
Formulation:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
Amino acids QDRSPILAEVKHSFYPC were used as the immunogen for the EAG1 antibody.
Limitation:
This EAG1 antibody is available for research use only.
Purity:
Antigen affinity purified
Uniprot #:
O95259