β-NF-JQ1

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TargetMol
Product Code: TAR-T10526
Supplier: TargetMol
CodeSizePrice
TAR-T10526-1mg1mg£148.00
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TAR-T10526-5mg5mg£229.00
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TAR-T10526-10mg10mg£309.00
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TAR-T10526-25mg25mg£510.00
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TAR-T10526-50mg50mg£703.00
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TAR-T10526-100mg100mg£938.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C

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Documents

Further Information

Bioactivity:
β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BRD)-containing proteins and induce AhR and BRD protein interactions. β-NF-JQ1 shows potent anticancer activity associated with protein knockdown activity. .
CAS:
2380000-55-3
Formula:
C45H42ClN5O6S
Molecular Weight:
816.36
Purity:
0.9945
SMILES:
CC=1C2=C(N3C([C@H](CC(NCCOCCOCCOCC4=CC=C(C=C4)C=5OC=6C(C(=O)C5)=C7C(=CC6)C=CC=C7)=O)N=C2C8=CC=C(Cl)C=C8)=NN=C3C)SC1C

References

Ohoka N, et al. Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins. ACS Chem Biol. 2019;14(12):2822-2832.