Bongkrekic acid
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Bongkrekic acid is a natural toxin first isolated from coconut tempeh contaminated with bacteria. It is a polyunsaturated long-chain fatty acid derivative that acts as a potent inhibitor of the mitochondrial adenine nucleotide (ADP/ATP) translocase (Ki < 2 nM). [1][2][3]Despite its high affinity, bongkrekic acid has a slow rate of action in intact preparations, as it must permeate the inner mitochondrial membrane to bind the translocase.[3]
CAS:
11076-19-0
Formula:
C28H38O7
Molecular Weight:
486.605
Purity:
0.98
SMILES:
CO[C@H](C\C=C/C=C/CC\C=C\C[C@H](C)\C=C\C(\CC(O)=O)=C/C(O)=O)C(\C)=C/C=C(\C)C(O)=O
References
Klingenberg, M. The ADP and ATP transport in mitochondria and its carrier. Biochimica et Biophysica Acta 1778(10), 1978-2021 (2008).
Dahout-Gonzalez, C., Hury, H., Tr?z?guet, V., et al. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda) 21, 242-249 (2006).
Henderson, P.J.F., and Lardy, H.A. Bongkrekic acid. An inhibitor of the adenine nucleotide translocase of mitochondria. The Journal of Biological Chemisty 245(6), 1319-1326 (1970).
Li F, Liu H, Wu X, et al.Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production.International Journal of Molecular Sciences.2023, 24(4): 3123.