20-carboxy Arachidonic Acid
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ? 0.12 uM) and PPARγ (Kd = 1.7 ? 0.5 uM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.
CAS:
79551-84-1
Formula:
C20H30O4
Molecular Weight:
334.456
Purity:
0.98
SMILES:
OC(=O)CCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O