SW2_110A acetate

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TargetMol
Product Code: TAR-T36798L
Supplier: TargetMol
CodeSizePrice
TAR-T36798L-1mg1mg£197.00
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Quantity:
TAR-T36798L-5mg5mg£326.00
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Quantity:
TAR-T36798L-10mg10mg£494.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T36798L-25mg25mg£870.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C

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Documents

Further Information

Bioactivity:
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate has a high affinity for CBX8N, inhibits the association between CBX8 and cell chromatin, and inhibits the proliferation of ML-AF9-induced THP1 leukemia cells.
Molecular Weight:
821.01
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
CCN(CCCC[C@H](NC([C@H](NC([C@H](C1CCCC1)NC(C2=CC=C(OC3=CC=CC=C3)C=C2)=O)=O)[C@@H](C)CC)=O)C(N[C@@H](CO)C(NCC#C)=O)=O)CC.CC(O)=O
Target:
Histone Methyltransferase

References

Wang S, et al. Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. ACS Chem Biol. 2020;15(1):112-13