4-oxo Docosahexaenoic Acid
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 uM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 uM.
CAS:
845673-74-7
Formula:
C22H30O3
Molecular Weight:
342.479
Purity:
0.98
SMILES:
CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C=C/C(=O)CCC(O)=O