TargetMol

UCB-5307

Product Code:
 
TAR-T61111
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T61111-1mg1mg£111.00
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TAR-T61111-5mg5mg£168.00
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TAR-T61111-10mg10mg£230.00
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TAR-T61111-25mg25mg£433.00
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TAR-T61111-50mg50mg£603.00
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Quantity:
TAR-T61111-100mg100mg£830.00
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Quantity:
TAR-T61111-500mg500mg£1,581.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pass through prefabricated hTNF/hTNFR1 complexes.
CAS:
1515887-44-1
Molecular Weight:
343.42
Pathway:
Apoptosis
Purity:
0.9802
SMILES:
OC(C=1C=CN=CC1)C2=NC=3C=CC=CC3N2CC4=CC(=CC=C4C)C
Target:
TNF

References

O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019;10(1):5795.