Vutiglabridin

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TargetMol
Product Code: TAR-T61268
Supplier: TargetMol
CodeSizePrice
TAR-T61268-1mg1mg£164.00
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TAR-T61268-5mg5mg£303.00
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TAR-T61268-1mL1 mL * 10 mM (in DMSO)£407.00
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TAR-T61268-10mg10mg£470.00
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TAR-T61268-25mg25mg£804.00
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TAR-T61268-50mg50mg£1,171.00
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TAR-T61268-100mg100mg£1,821.00
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TAR-T61268-500mg500mg£3,597.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C

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Documents

Further Information

Bioactivity:
Vutiglabridin is a novel and safe modulator of PON2, a racemic compound. vutiglabridin is an optimized structural analogue of Glabridin and is superior to Glabridin in terms of weight loss and chemical stability. vutiglabridin ameliorates mptp-induced neurodegeneration in Parkinson's disease mice by targeting mitochondrial paraoxonase-2. Vutiglabridin is a clinical phase 2 drug for the treatment of obesity and has therapeutic effects on p-mitochondrial PON2 in a PD model. vutiglabridin penetrates the brain, binds PON2, and restores 1-methyl-4-phenylpyridine (MPP*)-induced neuroblastoma in SH-SY5Y Vutiglabridin significantly attenuated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dyskinesia and dopaminergic neuronal damage in mice modeled with PD in mouse experiments.
CAS:
1800188-47-9
Formula:
C22H26O4
Molecular Weight:
354.44
Pathway:
Metabolism
Purity:
0.9781
SMILES:
OC1=CC(OCC)=CC=C1C2COC=3C(=CC=C4OC(C)(C)CCC43)C2
Target:
Phosphatase

References

Sulaiman D, et al. Vutiglabridin Modulates Paraoxonase 1 and Ameliorates Diet-Induced Obesity in Hyperlipidemic Mice. Biomolecules. 2023;13(4):687. Na JY, et al. Safety, tolerability, pharmacokinetic, and pharmacodynamic characteristics of vutiglabridin: A first-in-class, first-in-human study. Clin Transl Sci. 2022;15(11):2744-2757. Choi LS, et al. Discovery and preclinical efficacy of HSG4112, a synthetic structural analog of glabridin, for the treatment of obesity. Int J Obes (Lond). 2021;45(1):130-142. Bae IY, et al. Species Differences in Stereoselective Pharmacokinetics of HSG4112, A New Anti-Obesity Agent. Pharmaceutics. 2020;12(2):127.