TargetMol

AZA1

Product Code:
 
TAR-T61448
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T61448-1mg1mg£148.00
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TAR-T61448-5mg5mg£269.00
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TAR-T61448-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T61448-10mg10mg£389.00
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TAR-T61448-25mg25mg£603.00
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TAR-T61448-50mg50mg£830.00
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TAR-T61448-100mg100mg£1,099.00
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TAR-T61448-500mg500mg£2,135.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
CAS:
1071098-42-4
Formula:
C22H20N6
Molecular Weight:
368.43
Pathway:
Apoptosis|Cell Cycle/Checkpoint
Purity:
0.9859
SMILES:
N=1C=CC(=NC1NC=2C=CC=3NC(=CC3C2)C)NC=4C=CC=5NC(=CC5C4)C
Target:
Apoptosis|CDK|Rho

References

Pelin M, et al. Toxic equivalency factors (TEFs) after acute oral exposure of azaspiracid 1, -2 and -3 in mice. Toxicol Lett. 2018;282:136-146. Zins K, et al. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One. 2013;8(9):74924. Suzuki O, et al. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. Int J Oncol. 2015;47(6):2091-2099.