IRAK4-IN-20

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TargetMol
Product Code: TAR-T62714
Supplier: TargetMol
CodeSizePrice
TAR-T62714-1mg1mg£227.00
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TAR-T62714-5mg5mg£431.00
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TAR-T62714-1mL1 mL * 10 mM (in DMSO)£483.00
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Quantity:
TAR-T62714-10mg10mg£600.00
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Quantity:
TAR-T62714-25mg25mg£863.00
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Quantity:
TAR-T62714-50mg50mg£1,187.00
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Quantity:
TAR-T62714-100mg100mg£1,581.00
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TAR-T62714-500mg500mg£3,107.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C

Images

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Documents

Further Information

Bioactivity:
IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).
CAS:
1931994-80-7
Molecular Weight:
450.4541
Pathway:
Immunology/Inflammation|NF-κb
Purity:
0.9732
SMILES:
CC(C)(O)CCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(cc2n1)C(C)(C)O
Target:
IRAK

References

Li Q, Li R, Yin H, et al. Oral IRAK4 inhibitor BAY-1834845 prevents acute respiratory distress syndrome. Biomed Pharmacother. 2022;153:113459.