JI6

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TargetMol
Product Code: TAR-T64370
Supplier: TargetMol
CodeSizePrice
TAR-T64370-1mg1mg£201.00
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TAR-T64370-5mg5mg£375.00
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TAR-T64370-10mg10mg£527.00
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TAR-T64370-25mg25mg£804.00
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TAR-T64370-50mg50mg£1,058.00
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TAR-T64370-100mg100mg£1,420.00
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TAR-T64370-500mg500mg£2,769.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C

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Documents

Further Information

Bioactivity:
JI6 is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ~40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits c-Kit and JAK3, with IC50s of ~500 and ~250 nM, respectively. JI6 has research value in acute myeloid leukemia.
CAS:
856436-16-3
Molecular Weight:
383.42
Pathway:
Tyrosine Kinase/Adaptors|Angiogenesis
Purity:
0.9774
SMILES:
CS(=O)(O)=O.O=C(/C1=C\C2=CC=CN2)NC(C=C3)=C1C=C3C4=CN=CC=C4
Target:
FLT

References

Chen Y, et, al. Identification of an orally available compound with potent and broad FLT3 inhibition activity. Oncogene. 2016 Jun 9;35(23):2971-8.