Oxodipine
Code | Size | Price |
---|
TAR-T68123-1mg | 1mg | £132.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T68123-5mg | 5mg | £213.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T68123-10mg | 10mg | £279.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T68123-25mg | 25mg | £477.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T68123-50mg | 50mg | £625.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T68123-100mg | 100mg | £859.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T68123-500mg | 500mg | £1,653.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Images
Documents
Further Information
Bioactivity:
Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduced L-type Ca currents (I) with an IC of 0.24 uM, and against T-type Ca currents (I) with an IC of 0.41 uM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs.
CAS:
90729-41-2
Molecular Weight:
359.37
Pathway:
Membrane transporter/Ion channel|Metabolism
Purity:
0.9922
SMILES:
O=C(OC)C1=C(NC(=C(C(=O)OCC)C1C=2C=CC=C3OCOC32)C)C
Target:
Calcium Channel
References
Gal?n L, et al. Characteristics of Ca2+ channel blockade by oxodipine and elgodipine in rat cardiomyocytes. Eur J Pharmacol. 1998;357(1):93-105.
Tamargo J, et al. Effects of oxodipine on 45Ca movements and contractile responses in vascular smooth muscle. Br J Pharmacol. 1989;97(2):339-346.
Egros F, et al. An original intragastric delivery system for oral administration of solid formulations to fully conscious rats: its application to oxodipine studies. Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:71-76.
Montastruc P, et al. Effect of oxodipine, a novel dihydropyridine calcium channel blocker, in neurogenic hypertensive dogs. Arch Int Pharmacodyn Ther. 1993;321:57-62.
Tejerina T, et al. Effects of oxodipine on isolated rabbit aorta and mesenteric resistance vessels. Eur J Pharmacol. 1992;219(2):279-284.