TargetMol

Taurodeoxycholic acid

Product Code:
 
TAR-T75319
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T75319-1mg1mg£115.00
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TAR-T75319-5mg5mg£165.00
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TAR-T75319-10mg10mg£208.00
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TAR-T75319-25mg25mg£301.00
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TAR-T75319-50mg50mg£444.00
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TAR-T75319-100mg100mg£618.00
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Quantity:
TAR-T75319-500mg500mg£1,219.00
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This product comes from: United States.
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Further Information

Bioactivity:
Taurodeoxycholic acid is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.Taurodeoxycholic acid inhibits apoptosis by blocking calcium-mediated apoptotic pathways and by activation of caspase-12. Taurodeoxycholic acid has neuroprotective activity and has been used to study 3-nitropropionic acid-induced or stabilized hereditary Huntington's chorea (HD).
CAS:
516-50-7
Molecular Weight:
499.7
Pathway:
Membrane transporter/Ion channel|Apoptosis|Metabolism|Proteases/Proteasome
Purity:
0.9922
SMILES:
C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C[C@@H]1O)[H])[H])(CC[C@@]2([C@@H](CCC(NCCS(=O)(=O)O)=O)C)[H])[H]
Target:
Caspase|Apoptosis|Calcium Channel

References

Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002;36(3):592-601. Keene CD, et al. A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Exp Neurol. 2001;171(2):351-360. Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A. 2002;99(16):10671-10676. Benz C, et al. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. Eur J Clin Invest. 2000;30(3):203-209.