Excisanin A
| Code | Size | Price |
|---|
| TAR-TN4046-1mg | 1mg | £858.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-TN4046-5mg | 5mg | £3,926.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).
CAS:
78536-37-5
Formula:
C20H30O5
Molecular Weight:
350.45
Pathway:
GPCR/G Protein|NF-κb|Apoptosis|Chromatin/Epigenetic|DNA Damage/DNA Repair|Tyrosine Kinase/Adaptors|Angiogenesis|Cytoskeletal Signaling|Immunology/Inflammation|Proteases/Proteasome|MAPK|PI3K/Akt/mTOR signaling|Stem Cells
Purity:
0.98
SMILES:
CC1(C)CC[C@H](O)[C@@]2(C)[C@@H]3C[C@H](O)[C@@H]4[C@@H](O)[C@@]3([C@H](O)C[C@H]12)C(=O)C4=C
Target:
Prostaglandin Receptor|JNK|PI3K|Caspase|PARP|GSK-3|NF-κB|FAK|Akt|Wnt/beta-catenin|MMP