TargetMol

20-HETE

Product Code:
 
TAR-T14021
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T14021-100mg100mgEnquire
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Further Information

Bioactivity:
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity, and it also inhibits endothelial NO synthase and inhibits apoptosis of pulmonary artery smooth muscle cells[1][2]. 20-HETE constricts smooth muscles, stimulates smooth muscle proliferation and migration.
CAS:
79551-86-3
Formula:
C20H32O3
Molecular Weight:
320.47
Purity:
0.98
SMILES:
C(=C\C/C=C\C/C=C\CCCCCO)\C/C=C\CCCC(O)=O

References

Ding Y, et al. 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F753-63. Zou AP, et al. 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. Am J Physiol. 1996 Jan;270(1 Pt 2):R228-37. Li B, Ma Y, Tan L, et al. 20-Hydroxytetraenoic acid induces hepatic fibrosis via the TGF-?1/Smad3 signaling pathway. Toxicology Letters. 2022