HMG499
Code | Size | Price |
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TAR-T11572-5mg | 5mg | £1,167.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T11572-50mg | 50mg | £2,307.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T11572-100mg | 100mg | £2,898.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Images
Documents
Further Information
Bioactivity:
HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC 50 of 0.41 uM. HMG499 can eliminate statins-induced accumulation of HMGCR, lower serum cholesterol levels and decrease atherosclerosis [1].
CAS:
2416941-68-7
Formula:
C33H54O3
Molecular Weight:
498.78
Pathway:
Metabolism
Purity:
0.98
SMILES:
O[C@H](C1(C)C)CC[C@@]2(C)C1=C[C@H](O)C3C2CC[C@@]4(C)C3CC[C@@H]4[C@@H](CCCC(CC=C)(O)CC=C)C
Target:
HMG-CoA Reductase
References
Jiang SY, et al. Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol. Nat Commun. 2018 Dec 3;9(1):5138.