TargetMol

EMD 527040 hydrochloride

Product Code:
 
TAR-T41150
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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TAR-T41150-5mg5mgEnquire
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Further Information

Bioactivity:
EMD 527040 hydrochloride is an effective integrin αVβ6 inhibitor. The IC 50 values of EMD 527040 hydrochloride were 6 nM and 1.6 uM to inhibit αVβ6 binding to fibronectin and αVβ6 expression cells to fibronectin, respectively. EMD 527040 hydrochloride shows antifibrotic activity in animal models of biliary fibrosis and is active in vivo.
CAS:
2758431-92-2
Molecular Weight:
623.96
Purity:
0.98
SMILES:
O=C(CCCCNC1=CC=CC=N1)N[C@@H](COCC2=CC=CC=C2)C(NC(C3=CC(Cl)=CC(Cl)=C3)CC(O)=O)=O.Cl

References

Patsenker et al (2008) Inhibition of integrin ?v?6 on cholangiocytes blocks transforming growth factor-? activation and retards biliary fibrosis progression. Gastroenterology 135 660 PMID: 18538673