TargetMol

R-BC154

Product Code:
 
TAR-T41152
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-T41152-5mg5mgEnquire
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Further Information

Bioactivity:
R-BC154 is a high affinity fluorescent α4β1/α9β1 inhibitor (Kdvalues are 12.7 and 38 nM, respectively); fluorescent version of BOP. Rapidly and preferentially mobilizes HSCs and progenitorsin vivo. Excitation maximum, 561 nm; emissiosn maximum, 585 nm.
Purity:
0.98

References

Cao et al (2016) Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 7 11007 PMID: 26975966 Cao et al (2014) Design, synthesis and binding properties of a fluorescent ?9?1/?4?1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem. 12 965 PMID: 24363056