Thalidomide-Cyanine 5
| Code | Size | Price |
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| TAR-T41174-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Thalidomide-Cyanine 5 is a fluorescent probe for cereblon E3 ligases. Binds with high affinity to DDB1-CRBN. Suitable for use in TR-FRET.
Purity:
0.98
References
Chessum et al (2018) Demonstrating in-cell target engagement using a pirin protein degradation probe (CCT367766). J.Med.Chem. 61 918 PMID: 29240418
Petzold et al (2016) Structural basis of lenalidomide-induced CK1? degradation by the CRL4 CRBN ubiquitin ligase. Nature 532 127 PMID: 26909574
Cavadini et al (2016) Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome. Nature 531 598 PMID: 27029275
Fischer et al (2014) Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512 49 PMID: 25043012