Cyprodime hydrochloride
Code | Size | Price |
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TAR-T41185-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T41185-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T41185-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Images
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Further Information
Bioactivity:
Cyprodime hydrochloride is a highly selective u-opioid receptor antagonist with K i values of 5.4 nM, 244.6 nM and 2187 nM for u-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressive-like and anti-anxiety-like effect [1] [2].
CAS:
2387505-50-0
Molecular Weight:
391.94
Purity:
0.98
SMILES:
Cl.COc1cccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)CC[C@@]34OC)c12
References
Marki et al (1999) ?-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [ 35 S]GTP?s binding assays. Eur.J.Pharmacol. 383 209 PMID: 10585536
Schmidhammer et al (1995) Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. J.Med.Chem. 38 3071 PMID: 7636870
Henry et al (2001) ?- and ?-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Exp.Neurol. 171 139 PMID: 11520128