CAY10789

TargetMol
Product Code: TAR-T60439
Supplier: TargetMol
CodeSizePrice
TAR-T60439-5mg5mg£850.00
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Quantity:
TAR-T60439-50mg50mg£1,661.00
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Quantity:
TAR-T60439-100mg100mg£2,079.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C

Images

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Further Information

Bioactivity:
CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist with an IC50 of 2.80 uM. CAY10789 is also a GPBAR1 (G-protein-coupled bile acid receptor 1) agonist with an EC50 of 3 uM. CAY10789 significantly decreases the adhesion of U937 cells to HAEC and decreases the expression of TNF-α. CAY10789 exhibits very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used in the study of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases [1].
CAS:
123226-28-8
Molecular Weight:
265.312
Purity:
0.98
SMILES:
OCc1cccc(OCc2ccc3ccccc3n2)c1