TargetMol

CAY10789

Product Code:
 
TAR-T60439
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60439-5mg5mg£850.00
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Quantity:
TAR-T60439-50mg50mg£1,661.00
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Quantity:
TAR-T60439-100mg100mg£2,079.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist with an IC50 of 2.80 uM. CAY10789 is also a GPBAR1 (G-protein-coupled bile acid receptor 1) agonist with an EC50 of 3 uM. CAY10789 significantly decreases the adhesion of U937 cells to HAEC and decreases the expression of TNF-α. CAY10789 exhibits very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used in the study of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases [1].
CAS:
123226-28-8
Molecular Weight:
265.312
Purity:
0.98
SMILES:
OCc1cccc(OCc2ccc3ccccc3n2)c1