TargetMol

EGFR-IN-60

Product Code:
 
TAR-T63769
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T63769-5mg5mg£1,167.00
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Quantity:
TAR-T63769-50mg50mg£2,307.00
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Quantity:
TAR-T63769-100mg100mg£2,898.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
EGFR-IN-60 is an effective, orally active, safe antitumor agent. EGFR-IN-60 significantly inhibits EGFRWT (IC50: 83 nM), EGFRT790M (IC50: 26 nM), EGFRL858R (IC50: 53 nM) and JAK3 (IC50: 69 nM). IN-60 inhibited H1975 cells carrying the EGFRT790M mutation (IC50: 1.32 uM) and A431 cells overexpressing EGFRWT (IC50: 4.96 uM). EGFR-IN-60 increased the Bax/Bcl-2 ratio, which induced apoptosis induction and cell death.
CAS:
2699877-43-3
Molecular Weight:
535.47
Purity:
0.98
SMILES:
CN(C)c1ccc(C=Nn2cnc3NC4=C(C(c5cccc(Cl)c5Cl)c3c2=N)C(=O)CC(C)(C)C4)cc1