G12Si-5
Code | Size | Price |
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TAR-T64059-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T64059-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T64059-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
G12Si-5 is a covalent inhibitor of the K-RasG12S mutant with a Ki value of 26 uM. G12Si-5 binds to the S-IIP structural domain and inhibits oncogenic signalling. g12Si-5 reduces ERK phosphorylation levels in KRAS G12S mutant cells.
CAS:
2946593-46-8
Formula:
C31H29ClFN5O3
Molecular Weight:
574.04
Purity:
0.98
SMILES:
C(OC=1N=C(C2=C(N1)C(F)=C(N=C2)C=3C4=C(C=CC3)C=CC=C4Cl)N5C[C@]6([C@@](CC5)(C(=O)O6)[H])[H])C78N(CCC7)CCC8